As a locum tenens worker, you'll find you have new responsibilities when it comes to taxation. Your status as an independent contractor, coupled with the fact that you may work in several different states over the course of a year, adds to the complexities you will face come tax time. You may be required to file in several states, and you will almost certainly face expenses that other medical employees never have to deal with.
Of course, these annual headaches are greatly outweighed by the many benefits to locum tenens work. You are likely to earn more money and gain more control over your schedule. Additionally, you can also enjoy a variety of write-offs designed to reduce your tax burden since you're virtually acting as your own employer, to an extent.